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Schizophrenia is a cypher to science. It is an inherited disease, yet it does not go strictly from one generation to the next. It may skip a few. There are even arguments that schizophrenia may be caused by environmental instead of genetic factors. But one thing most schizophrenics have in common:

They smoke. A lot.

Researchers at the University of Buffalo believe that schizophrenics smoke because nicotine is a form of self-medication, and that by working with smoking cessation drugs (nicotinic agonists, they call that), doctors may be able to help repair cognitive functions of the sufferers.

How is this possible? They believe they have discovered a single genetic pathway, or series of DNA segments that work together, that controls as many as 160 different traits, all associated with the disease:

 “How is it possible to have 100 patients with schizophrenia and each one has a different genetic mutation that causes the disorder?” asks Stachowiak. “It’s possible because INFS integrates diverse neurological signals that control the development of embryonic stem cell and neural progenitor cells, and links pathways involving schizophrenia-linked genes.

“INFS functions like the conductor of an orchestra,” explains Stachowiak. “It doesn’t matter which musician is playing the wrong note, it brings down the conductor and the whole orchestra. With INFS, we propose that when there is an alteration or mutation in a single schizophrenia-linked gene, the INFS system that controls development of the whole brain becomes untuned. That’s how schizophrenia develops.”

The link between smoking and schizophrenia is well-established. Because there is such a strong, common link between smoking and this otherwise disparately symptomatic disease, researchers believe that nicotine and nicotinic agonists may be affecting this pathway.